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Scientists identify new gene differences in severe COVID patients

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2 years ago

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  • The scientists said their discoveries, could help prioritise the likely treatments that could work against the disease.
  • The information could even help predict which patients were likely to become severely ill.
  • The new findings could help guide scientists in their search for existing drugs that might be useful for treating COVID-19.

Scientists have pinpointed 16 new genetic variants in people who developed severe COVID-19 in a large study published on Monday that could help researchers develop treatments for very sick patients.

The results suggest that people with severe COVID have genes that predispose them to one of two problems: failure to limit the ability of the virus to make copies of itself, or excessive inflammation and blood clotting.

The scientists said their discoveries, published in the journal Nature, could help prioritise the likely treatments that could work against the disease.

Eventually, the information could even help predict which patients were likely to become severely ill.

“It is potentially possible in future that we will be able to make predictions about patients based on their genome at the point of presenting (for) critical care,” said Kenneth Baillie, consultant in critical care medicine at the University of Edinburgh and one of the study authors, told reporters.

The genetic analysis of nearly 56,000 samples from people in Britain showed differences in 23 genes in COVID-19 patients who became critically ill, when compared with the DNA of other groups included in the study, including 16 differences that had not been previously identified.

The new findings could help guide scientists in their search for existing drugs that might be useful for treating COVID-19.

For example, the researchers found changes in key genes that regulate the level of factor VIII, a protein involved in forming blood clots.

“Blood clotting is one of the main reasons why patients with COVID develop a shortage of oxygen. So that’s potentially targetable to prevent those clots from forming,” Baillie said.

But “we can’t know if these medicines will work until we try them in people”.

One of the previously discovered genes, TYK2, is targeted by Eli Lilly’s arthritis drug baricitinib, now being studied as a treatment for COVID-19.

The drug was shown last week to cut the risk of death and hospitalisation in COVID-19 patients by 13% in a trial.

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PM Shehbaz will meet with Saudi ministers and speak at the WEF special session today.

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3 hours ago

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On the third day of his visit to the Kingdom, Prime Minister Shehbaz Sharif will speak at the World Economic Forum Special Meeting’s final plenary, which is titled “Rejuvenating Growth.”

Other speakers at the concluding plenary, in addition to the prime minister, are Saudi Arabia’s Minister of Economy and Planning Faisal Alibrahim, British Secretary of State David Cameron, WEF Geneva President Brørge Brende, and WEF Head of Middle East and North Africa Maroun Kairouz.

Meetings with Saudi ministers of trade, energy, the environment, and agriculture are also scheduled for the third day of the prime minister’s visit. He will probably also meet with his counterpart from Malaysia.

Mohammed bin Salman, the prime minister and crown prince of Saudi Arabia, will be present at the World Economic Forum’s (WEF) Special Meeting on Global Collaboration, Growth, and Energy for Development, which gets underway here today.

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The nomination of Ishaq Dar as deputy prime minister raises concerns.

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3 hours ago

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A lot of doubts have been raised by Ishaq Dar, the foreign minister, being appointed deputy prime minister.

No reference to the Constitution, regulations, or any other law was mentioned in the Cabinet Division’s notification of the appointment.

What powers Prime Minister Shehbaz Sharif used to designate Ishaq Dar as deputy prime minister has come under scrutiny in light of this.

There are questions about the legal foundation for the deputy prime minister’s nomination as it appears from the notification’s phrasing that rules for the position have not yet been established, according to insiders.

Likewise, the announcement is vague about the deputy prime minister’s proposed authority.

Deputy prime minister would be purely symbolic, according to government sources, and would not be authorized to carry out prime ministerial duties. In Pakistan, the deputy prime minister has previously been nominated.

The PPP administration appointed Chaudhry Parvez Elahi as deputy prime minister.

Observe that Foreign Minister Ishaq Dar was appointed deputy prime minister on Sunday with Prime Minister Shehbaz Sharif’s consent; the Cabinet Division formally announced the appointment.

Dar holds the position of Pakistan’s fourth deputy prime minister. Previous appointments to the position of deputy prime ministers included Parvez Elahi, Zulfikar Ali Bhutto, and Begum Nusrat Bhutto.

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The green colour of WhatsApp ‘angers’ some users.

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3 hours ago

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After changing its display colour from blue to green, WhatsApp, which was before well-known for its blue motif, caused its users to hold divergent views.

New upgrades to the Meta app always spark a lot of discussion, regardless of how big or small the changes are.

Still, Meta-owned WhatsApp hopes that these modifications would “make it more accessible as well as easier to use” and offer a “modern, new experience” with relation to the updated display color.

A statement from the firm claimed that they had altered WhatsApp’s “looks and feels, including spacing, colors, icons, and more.”

Both iOS and Android users can now view the new WhatsApp update; the green tint on the latter has changed from the previous version.

However, iPhone users will notice that every display element, including the chat-list window and status bar, has changed with the recent design update. WhatsApp used to have a blue color scheme on iPhones.

Furthermore, the formerly blue links shared within the app are now displayed in green.

In addition, WhatsApp has made other improvements to improve its user experience outside of the color shift.

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