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Scientists identify new gene differences in severe COVID patients

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  • The scientists said their discoveries, could help prioritise the likely treatments that could work against the disease.
  • The information could even help predict which patients were likely to become severely ill.
  • The new findings could help guide scientists in their search for existing drugs that might be useful for treating COVID-19.

Scientists have pinpointed 16 new genetic variants in people who developed severe COVID-19 in a large study published on Monday that could help researchers develop treatments for very sick patients.

The results suggest that people with severe COVID have genes that predispose them to one of two problems: failure to limit the ability of the virus to make copies of itself, or excessive inflammation and blood clotting.

The scientists said their discoveries, published in the journal Nature, could help prioritise the likely treatments that could work against the disease.

Eventually, the information could even help predict which patients were likely to become severely ill.

“It is potentially possible in future that we will be able to make predictions about patients based on their genome at the point of presenting (for) critical care,” said Kenneth Baillie, consultant in critical care medicine at the University of Edinburgh and one of the study authors, told reporters.

The genetic analysis of nearly 56,000 samples from people in Britain showed differences in 23 genes in COVID-19 patients who became critically ill, when compared with the DNA of other groups included in the study, including 16 differences that had not been previously identified.

The new findings could help guide scientists in their search for existing drugs that might be useful for treating COVID-19.

For example, the researchers found changes in key genes that regulate the level of factor VIII, a protein involved in forming blood clots.

“Blood clotting is one of the main reasons why patients with COVID develop a shortage of oxygen. So that’s potentially targetable to prevent those clots from forming,” Baillie said.

But “we can’t know if these medicines will work until we try them in people”.

One of the previously discovered genes, TYK2, is targeted by Eli Lilly’s arthritis drug baricitinib, now being studied as a treatment for COVID-19.

The drug was shown last week to cut the risk of death and hospitalisation in COVID-19 patients by 13% in a trial.

Education

Students from Balochistani start their academic adventure in China.

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China is the destination of ten Gwadar Institute of Technology (GIT) students who are going there for school. They will be pursuing Associate Engineering Diplomas at Hebei Jiaotong Vocational and Technical College after being chosen for the Sino-Pak Dual Diploma Program.

These students had the privilege of seeing the Chinese Consul General in Karachi prior to their departure, where they were greeted with warmth and given support for their future ambitions.

These ten people, who are from Pasni, Turbat, Kech, Panjgur, Gwadar, and Surab, among other places, exemplify the talent and diversity of Balochistan.

The Government of Balochistan and the well-known Chinese corporation Tang are supporting this opportunity, which gives these youngsters a grant to help with their study overseas.

The children would want to express their sincere gratitude to the Pakistan Army and the Government of Balochistan for making this opportunity possible.

They are excited to take advantage of this opportunity to continue their studies and support Balochstan’s growth, especially through initiatives like the China-Pakistan Economic Corridor (CPEC).

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Amid controversy surrounding judges’ letters, PM Sharif will meet with CJP Isa today.

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Today’s key meeting between Pakistan’s Chief Justice, Qazi Faez Isa, and Prime Minister Shehbaz Sharif is planned in the midst of ongoing discussions regarding a letter sent by six justices of the Islamabad High Court regarding outside meddling in court cases.

Azam Nazir Tarar, the minister of law, and Mansoor Usman Awan, the attorney general for Pakistan, are expected to accompany Prime Minister Sharif to the CJP meeting.

The meeting follows a full court session that CJP Isa called on Wednesday, with the express purpose of addressing issues brought up in a letter signed by six judges of the Islamabad High Court.

All of the participating judges carefully examined the letter’s contents during the session, analyzing both its constitutional and legal consequences. Discussions about the letter’s publication’s legal and constitutional ramifications were also included in the session.

All of the judges actively participated in the lengthy two hours and twelve minute discussion, offering their thoughts on the subject at hand.

According to sources, the top judge of Pakistan is expected to chair another full court meeting today. It is anticipated that this session would examine the letter’s contents in greater detail, with additional evaluation and discussion among the SC judges.

On Wednesday, the bar associations of the High Courts of Islamabad, Lahore, Sindh, and Balochistan urged that the CJP conduct a “transparent inquiry” into the matter and that those responsible for it face legal repercussions.

Its cabinet “strongly condemned the interference of one institution into the matters of another institution,” according to a press release from the IHCBA.

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Jordan and Pakistan emphasize how vital a ceasefire in Gaza is.

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Jordan’s Deputy Prime Minister and Foreign Minister, Ayman Safadi, called Foreign Minister Ishaq Dar on Wednesday.

Foreign Minister Dar said on his X timeline that during the discussion, they talked about the state of affairs in Gaza and denounced the actions of Israel.

The two leaders demanded that help be sent to Gaza without hindrance.

“I am excited to collaborate closely with the foreign minister of Jordan to develop our bilateral relations into a multi-level partnership,” he said.

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