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Migraine drugs may also help with weight loss

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Researchers at UT Southwestern revealed in a new study that Triptans, a common migraine drug, can also help those struggling to lose weight.

The study focused on examining obesity in mice and found that a daily dose of Triptan led them to lose weight in approximately a month.

“We’ve shown that there is real potential to repurpose these drugs, which are already known to be safe, for appetite suppression and weight loss,” said lead study author, Chen Liu PhD.

Beforehand, scientists already knew that serotonin, a chemical messenger in the brain and body, plays an important role in determining one’s appetite. But there are 15 different serotonin receptors that trigger a behavioural change in cells.

This new experiment revealed that Triptans target the serotonin 1B receptor, which hadn’t been studied closely before in analyzing appetite and weight loss.

To conduct the study, researchers fed obese mice a high-fat diet for seven weeks. After 24 days, mice given Truptan lost 3.6 per cent of their body weight while mice that weren’t given the drug gained 5.1 per cent.

“We found that these drugs, and one in particular, can lower body weight and improve glucose metabolism in less than a month, which is pretty impressive,” said Dr Liu.

The study was published in the Journal of Experimental Medicine.

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11 are killed and other coal workers are injured in the Harnai blast.

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An explosion in the Shahrag neighborhood of the Harnai region of Balochistan on Friday claimed the lives of at least 11 persons and injured a number more.

Police say the explosion happened close to a car that was transporting coal mine personnel. They said that numerous injured people are in critical condition.

After arriving at the scene, law enforcement officers began gathering evidence.

Eleven laborers were confirmed dead in the explosion by the deputy commissioner of Harnai. Swat and Shangla were responsible for the majority of the fatalities and injuries.

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Ties Between Pakistan and Turkey: Pakistan Is Our Second Home Erdoğan Emine

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Emine Erdoğan, the First Lady of Turkey, has underlined the pressing need for international environmental action.
Speaking at the Environmental Sustainability event in Islamabad, Emine Erdoğan emphasized the two nations’ long-standing friendship.
Chief Minister Punjab Maryam Nawaz also addressed the event.

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Terrorism Out of the Nation: Security Forces Kill 13 Khwarij in Five KP Engagements

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In five separate encounters in the region of Khyber Pakhtunkhwa, security forces have killed thirteen Khwarij.
ISPR reports that security personnel carried out an intelligence-based operation in the general vicinity of Khulachi, Dera Ismail Khan District, in response to the reported presence of Khwarij.
During the conduct of operation, own troops effectively engaged the Khwarij Location, resultantly, Five Khwarij including Kharji Shah Gul Alias Rohani were sent to hell.
In two separate encounters in north Waziristan District, fire exchange took place between the security forces and Khwarij in general areas Dosali and Tappi. Resultantly, five Khwarij were effectively neutralized by own troops.

In another encounter that took place in Lakki Marwat District, Two Khwarij were sent to hell.

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